PROTEOMIC STUDY OF CARBAPENEM-RESISTANT K. PNEUMONIAE CLINICAL ISOLATES

Objective: Now it's a worldwide issue that carbapenem resistance is spreading. This has made K. pneumoniae infections more difficult to treat. All Klebsiella pneumonia's proteins were examined in this study, which focused on the carbapenem-resistant bacteria's response meropenem. Methods: Proteomics (MALDI-TOF) and bioinformatics methods combined answer new enigma of resistance. Functional annotation, pathway enrichment protein–protein interaction some uses data. Both KEGG STRING played an important role (PPI). Results: Proteins help synthesise DNA RNA, aid degradation, energy intermediate metabolism are all subdivided into two classes.007A Conclusion: Bacterial survival meropenem may have been aided by four overexpressed their partners. A anti-resistance medication based these could restrict growth "bad bugs."